The Peter Attia Drive

In this episode, Stanley Perlman shares insights from his impressive career studying coronaviruses—both the common and more deadly ones, like MERS and SARS. In comparing preceding coronaviruses with SARS-CoV-2, Stanley discusses how other coronaviruses can aid our current understanding of, and be used to infer about, COVID-19. He also gives his thoughts on durable immunity, therapeutic strategies, and future outbreak preparedness.

We discuss:

His background and early work with coronaviruses [2:45];
The coronavirus family—various types, common traits, and scientific understanding [9:00];
The origin of viruses, animal to human transmission, R_0, immunity, and more [17:45];
Insights from the 2002 SARS outbreak [28:30];
Insights from the 2012 MERS outbreak [35:00];
Comparing SARS-CoV-2 to MERS, SARS, and other coronaviruses [42:00];
COVID-19 survivor potential for long-term damage [53:30];
Using the current pandemic for lessons on future preparedness [57:00];
Genetic drift and the potential for long-term immunity to COVID-19 [1:07:00];
Prevention and treatment strategies for COVID-19 and future diseases [1:22:30];
Alternative hypothesis to the origin of SARS-CoV-2 [1:32:30];
Determining durable immunity to COVID-19 and what a successful vaccine looks like [1:34:30]; and
More.

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#117 - Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19